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Diazepam Treatment Does Not Influence the Debrisoquine or Mephenytoin Hydroxylation Phenotyping Tests

 

作者: Eduardo Spina,   Anna Buemi,   DREmilio Sanz,   DRLeif Bertilsson,  

 

期刊: Therapeutic Drug Monitoring  （OVID Available online 1989）
卷期: Volume 11, issue 6  

页码: 721-723

 

ISSN:0163-4356

 

年代: 1989

 

出版商: OVID

 

关键词: Key WordsDiazepam;Debrisoquine;Mephenytoin;Hydroxylation polymorphism.

 

数据来源: OVID

 

摘要:

Debrisoquine and S-mephenytoin hydroxylation phenotyping tests were performed in 9 patients before and during treatment with diazepam at a daily dose of 10 or 15 mg. There was no change in either the debrisoquine/ 4-hydroxydebrisoquine ratio or the ratio of S/R mephenytoin in urine. The hydroxylation of these two test drugs is apparently not inhibited by administration of therapeutic doses of diazepam.

 

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