Psychological Stress, Cytokine Production, and Severity of Upper Respiratory Illness
作者:
Sheldon Cohen,
William J. Doyle,
David P. Skoner,
期刊:
Psychosomatic Medicine
(OVID Available online 1999)
卷期:
Volume 61,
issue 2
页码: 175-180
ISSN:0033-3174
年代: 1999
出版商: OVID
数据来源: OVID
摘要:
ObjectiveThe purpose of this study is to assess the role of psychological stress in the expression of illness among infected subjects and to test the plausibility of local proinflammatory cytokine production as a pathway linking stress to illness.MethodsAfter completing a measure of psychological stress, 55 subjects were experimentally infected with an influenza A virus. Subjects were monitored in quarantine daily for upper respiratory symptoms, mucus production, and nasal lavage levels of interleukin (IL)-6.ResultsHigher psychological stress assessed before the viral challenge was associated with greater symptom scores, greater mucus weights, and higher IL-6 lavage concentrations in response to infection. The IL-6 response was temporally related to the two markers of illness severity, and mediation analyses indicated that these data were consistent with IL-6 acting as a major pathway through which stress was associated with increased symptoms of illness. However, this pattern of data is also consistent with increases in IL-6 occurring in response to tissue damage associated with illness symptoms.ConclusionsPsychological stress predicts a greater expression of illness and an increased production of IL-6 in response to an upper respiratory infection.
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