Integrated Pharmacokinetic-Dynamic Modeling of Drugs Acting on the CNS
作者:
PaalzowLennart K.,
期刊:
Drug Metabolism Reviews
(Taylor Available online 1984)
卷期:
Volume 15,
issue 1-2
页码: 383-400
ISSN:0360-2532
年代: 1984
DOI:10.3109/03602538409015073
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThis paper has attempted to review some of the possibilities we have today to describe the relationships between the kinetics of a drug and the pharmacodynamic responses. In the future we should place a great deal of effort not only on a detailed evaluation of drug absorption and disposition in the body but also on a much more careful characterization of the dose (concentration)-effect relationships. This should be done in vivo, in order to be able to evaluate the complex character of an observed pharmacological effect, and in a dose range as wide as possible. Although not discussed in the present communication, the possibility of active metabolites must always be considered.
点击下载:
PDF (597KB)
返 回