The Short Child with Subnormal Plasma Somatomedin C
作者:
DANIEL RUDMAN,
MICHAEL KUTNER,
RAJENDER CHAWLA,
期刊:
Pediatric Research
(OVID Available online 1985)
卷期:
Volume 19,
issue 10
页码: 975-980
ISSN:0031-3998
年代: 1985
出版商: OVID
数据来源: OVID
摘要:
In 59 male and 59 female healthy children of average stature between 7 and 10 yr old, the normal range of plasma somatomedin C was investigated. The 95% tolerance limits narrowed progressively when the child's plasma somatomedin C status was described by the mean of one, two, three, or four determinations at 6-wk intervals. The 95% tolerance limits were therefore based on the mean of four determinations. In 97 children, age 7 to 10, below the 3.0 percentile in height, 44 had an average plasma somatomedin C below the 2.5 percentile. Among these hyposomatomedinemic short children, 19 were partially or totally deficient in growth hormone, 20 had normal immunoreactive growth hormone responses to dopa, glucagon, and sleep (nongrowth hormone deficient), and five had borderline provocative tests. Both growth hormone deficient and nongrowth hormone deficient children showed significant linear growth responses to 6-month courses of human growth hormone (0.16 to 0.70 unit/kg/wk). The responses of the latter group were 50 to 90% as great as those of the former.
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