Stereoselective and Asymmetric-Selective Polymerization of α-Amino Acid N-Carboxyanhydride
作者:
Y. Imanishi,
Y. Hashimoto,
期刊:
Journal of Macromolecular Science: Part A - Chemistry
(Taylor Available online 1979)
卷期:
Volume 13,
issue 5
页码: 673-693
ISSN:0022-233X
年代: 1979
DOI:10.1080/00222337908056681
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The enantiomer selectivity in the propagation reaction of NCA was investigated by using suitable model reactions. Contrary to the assumption usually made, the enantiomer selectivity in the nucleophilic addition of chiral amines to NCA depended strongly on the structure of amine or NCA and the solvent. In the polymerization by an activated-NCA mechanism, the addition of activated NCA to NCA was found for the first time to be enantiomer-selective. In addition to this, the chiral penultimate unit was found to participate in the enantiomer selection. Structures of the transition states leading to the different types of enantiomer selection were proposed.
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