Disseminated, Multiclonal Epstein‐Barr Virus‐Associated Lymphoproliferative Disease in a Patient with Hematological and Immunological Anomalies Molecular Analysis Correlates with Morphological Appearance
作者:
Jane Armes,
Simone Eades,
Melissa Southey,
Bruce Ross,
Jonathan Carapetis,
Chung Chow,
Deon Venter,
期刊:
Diagnostic Molecular Pathology
(OVID Available online 1995)
卷期:
Volume 4,
issue 1
页码: 39-47
ISSN:1052-9551
年代: 1995
出版商: OVID
关键词: Lymphoproliferative disorder;Epstein-Barr virus;Polymerase chain reaction;Abnormalities.
数据来源: OVID
摘要:
We report a case of a 21-year-old woman with hematopoietic. immunological, and congenital dysmorphic abnormalities, who died following rapidly progressive, disseminated Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD). Polymerase chain reaction (PCR) amplification of formalin-fixed paraffin-embedded tissue showed differences in the clonality of each separate lymphoproliferative lesion examined, as determined by immunoglobulin heavy chain (IgH) gene rearrangement. PCR analysis also demonstrated that all lesions contained EBV genome. Since DNA had been extracted from paraffin blocks, a direct comparison of morphology and clonality could be made in each individual lesion. The evidence from this study indicates that the monoclonal tumors arose de novo in multiple sites and that the polyclonal background observed in some lesions reflected a substantial concomitant inflammatory response.
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