A Case Report of Olanzapine-Induced Hypersensitivity Syndrome
作者:
Ayelet Raz,
Reuven Bergman,
Oron Eilam,
Tal Yungerman,
Tony Hayek,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 2001)
卷期:
Volume 321,
issue 2
页码: 156-158
ISSN:0002-9629
年代: 2001
出版商: OVID
关键词: Olanzapine;Hypersensitivity syndrome.
数据来源: OVID
摘要:
Hypersensitivity syndrome is defined as a drug-induced complex of symptoms consisting of fever, rash, and internal organ involvement. The hypersensitivity syndrome is well recognized as being caused by anticonvulsants. Olanzapine is an atypical antipsychotic agent whose side effects include sedation, weight gain, and increased creatinine kinase and transaminase levels. To date, there have been no reports of hypersensitivity syndrome related to this drug. A 34-year-old man developed a severe generalized pruritic skin eruption, fever, eosinophilia, and toxic hepatitis 60 days after ingestion of olanzapine. After termination of olanzapine treatment, the fever resolved, the skin rash was reduced, eosinophil count was reduced to normal, and the transaminase levels were markedly reduced. Clinical features and the results of skin and liver biopsies indicated that the patient developed hypersensitivity syndrome caused by olanzapine.
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