The control of IgM expression in a murine B cell lymphoma
作者:
Holly A. Irick,
Carol H. Sibley,
期刊:
Developmental Genetics
(WILEY Available online 1983)
卷期:
Volume 4,
issue 1
页码: 31-48
ISSN:0192-253X
年代: 1983
DOI:10.1002/dvg.1020040104
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: B cell development;IgM;mouse;tumor metastasis
数据来源: WILEY
摘要:
AbstractThe regulation of IgM expression was studied in clones derived from a murine B lymphocyte cell line, WEHI279.1. During normal B cell development IgM heavy chain synthesis increases concomitantly with heightened IgM secretion and reduced cell‐surface IgM. However, in these subclones, the levels of membrane‐bound and secreted IgM were regulated independently of one another. The amount of IgM secreted by the cells was tightly coupled to the amount of heavy chain synthesis, suggesting that the major control of secretion is pretranslational. Surface IgM exhibited a more complex regulation, with both pre‐ and posttranslational components. Variation in the expression of both forms of IgM occurred at high frequency. Although IgM expression follows a unidirectional pathway in nontransformed cells, the variability in these tumor cells was reversible and cellautonomous. High levels of phenotypic variability may be important in the ability of transformed cells to escape the immune res
点击下载:
PDF
(2240KB)
返 回