Synthesis of Non-glucosamino Glucan Oligosaccharides Related to Heparin and Heparan Sulphate
作者:
Jacob Westman,
Marianne Nilsson,
期刊:
Journal of Carbohydrate Chemistry
(Taylor Available online 1995)
卷期:
Volume 14,
issue 7
页码: 949-960
ISSN:0732-8303
年代: 1995
DOI:10.1080/07328309508005387
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A series of three oligosaccharides, α-d-Glc-(1→4)-β-d-GlcA-1ωe, β-d-GlcA-(1→4)-α-d-Glc-(1→4)-β-d-GlcA-lωe and α-d-Glc-(1→4)-β-d-GlcA-(1→4)-α-d-Glc-(1→4)-β-d-GlcA-1ωe was prepared by a short synthetic route, using maltose and glucuronic acid derivatives as starting materials. The oligosaccharides contain glucose residues instead of glucosamines, and have a less complicated structure than the corresponding unsulphated structures found in native heparin and heparan sulphate. This simplification in structure has diminished the number of synthetic steps and raised the total yield compared to the preparation of the corresponding heparin/heparan sulphate structures which have been found to bind acidic and basic FGF.
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