Expression of IGF-I and IGF-II genes in the adult rat eye
作者:
DaniasJohn,
StylianopoulouFotini,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 4
页码: 379-386
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008999626
出版商: Taylor&Francis
数据来源: Taylor
摘要:
We have investigated the transcription of IGF-I and IGF-II genes in the adult rat eye. Each eye was dissected into cornea, lens, sclera+choroid+pigment epithelium, and neural retina. Total cellular RNA was isolated from each of these tissues. Northern blot analysis using rat coding region cDNA probes revealed the presence of IGF-I and IGF-II specific transcripts in the retina and the sclera but not in the lens and cornea. Retina demonstrated the highest level of IGF-I and IGF-II expression. Our results suggest autocrine and paracrine effects of the IGFs and their possible involvement in normal eye physiology as well as in the pathogenesis of certain eye diseases.
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