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Regioselective Alkylation and Arylation At The 6-Position Of Pyrimidine: Synthesis Of 5- Alkyl-6-Arylmethyl-2,4-Pyrimidinediones

 

作者: YeonSoo Lee,   YongHae Kim,  

 

期刊: Synthetic Communications  （Taylor Available online 1999）
卷期: Volume 29, issue 9  

页码: 1503-1517

 

ISSN:0039-7911

 

年代: 1999

 

DOI:10.1080/00397919908086130

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

5-Alkyl-2,4,6-trichloropyrimidines reacted with various nucleophiles to afford the regioselectively 6-substituted pyrimidines as the major products in good yields, which were transformed to 5-alkyl-6-arylmethyl-2,4-pyrimidinediones of a key intermediate of MKC-442.

 

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