Ultrastructural evidence for the presence of ferritin‐iron in the biliary system of patients with iron overload
作者:
Maud I. Cleton,
Jan W. Sindram,
Louk H. P. M. Rademakers,
Floris M. J. Zuyderhoudt,
Willem C. De Bruijn,
Joannes J. M. Marx,
期刊:
Hepatology
(WILEY Available online 1986)
卷期:
Volume 6,
issue 1
页码: 30-35
ISSN:0270-9139
年代: 1986
DOI:10.1002/hep.1840060107
出版商: W.B. Saunders
数据来源: WILEY
摘要:
AbstractFerritin‐like particles were observed in bile canaliculi of patients with iron overload. These particles have been further investigated by: (1) a staining method enhancing the size and contrast of ferritin protein, and (2) electronprobe microanalysis detecting the presence of the elements iron and phosphorus.Morphological observation of coated vesicles in the cytoplasm adjacent to the bile canaliculi and coated pits in the canalicular membrane suggests a transport mechanism via membrane‐bound organelles.Support is given to the theory that part of the iron, stored in the liver, leaves the hepatocyte by excretion of ferritininto the b
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