Role of Nitric Oxide in Exercise‐Induced Vasodilation of the Forearm
作者:
Toyonari Endo,
Tsutomu Imaizumi,
Tatsuya Tagawa,
Masanari Shiramoto,
Shin-ichi Ando,
Akira Takeshita,
期刊:
Circulation
(OVID Available online 1994)
卷期:
Volume 90,
issue 6
页码: 2886-2890
ISSN:0009-7322
年代: 1994
出版商: OVID
关键词: blood flow;endothelium-derived factors;exercise
数据来源: OVID
摘要:
BackgroundWe wished to determine the role of NO in exercise-induced metabolic forearm vasodilation.Methods and ResultsYoung healthy volunteers (n = 11) underwent static handgrip exercise (4 to 5 kg, 3 minutes). Forearm blood flow (FBF) measured by strain plethysmography increased from 4.1 ± 0.7 mL.min−1·100 mL−1at rest to 9.8 ± 1.2 mL·min−1·100 mL−1immediately after exercise and gradually decreased thereafter. Exercise was repeated after intrabrachial artery infusion ofNG-monomethyl-L-arginine (L-NMMA) at 4.0 μmol/min for 5 minutes. L- NMMA did not alter blood pressure and heart rate. L-NMMA decreased FBF at rest to 2.9 ± 0.4 mL.min-1.100 mL−1(P< .01), peak FBF immediately after exercise to 7.2 ± 0.7 mL.min−1.100 mL−1(P< .01), and FBF during the mid to late phase of metabolic vasodilation (P< .01). Calculated oxygen consumption during peak exercise was comparable before and after L-NMMA. Intra-arterially infused L-arginine (10 mg/min, 5 minutes) reversed the inhibitory effect of L-NMMA. To determine the effect of the decrease in resting FBF on exercise-induced hyperemia, we normalized FBF after exercise by resting FBF. The percent increases in FBF after exercise from resting FBF were similar before and after L-NMMA. Furthermore, we examined the effect of intra-arterially infused angiotensin II on FBF at rest and after exercise (n = 7). Angiotensin II decreased FBF at rest from 3.1 ± 0.3 to 1.8 ± 0.3 mL.min−1.100 mL−1(P< .01), peak FBF after exercise from 8.1 ± 0.5 to 5.6 ± 0.5 mL.min−1.100 mL−1(P< .01), and FBF during the mid to late phase of metabolic vasodilation. The effects of L-NMMA and angiotensin II on FBF at rest and exercise were similar.ConclusionsOur results suggest that L-NMMA decreased FBF after exercise largely by decreasing resting FBF. These results suggest that NO may not play a significant role in exercise-induced metabolic arteriolar vasodilation in the forearm of healthy humans.
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