The Frequency of Revertants in mdx Mouse Genetic Models for Duchenne Muscular Dystrophy
作者:
ISTVAN,
DANKO VERNE,
CHAPMAN JON,
期刊:
Pediatric Research
(OVID Available online 1992)
卷期:
Volume 32,
issue 1
页码: 128-131
ISSN:0031-3998
年代: 1992
出版商: OVID
数据来源: OVID
摘要:
The mdx mouse has been used for the development of cellular and gene therapies for Duchenne muscular dystrophy. The relatively frequent occurrence of dystrophin-positive muscle cells called revertants has hampered these efforts by interfering with data interpretation. The mdx4cvand mdx5cvdystrophin mouse mutants have approximately 10-fold fewer revertants than the mdx mutant at both 2 and 6 mo. The mdx3cvdystrophin mouse mutant may be a useful model for some types of human dystrophin deficiencies in which the levels of dystrophin are low but not completely absent.
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