&NA;The NPT7 (Radiometer Medical A/S, Copenhagen, Denmark) point of care blood gas analyzer was evaluated in a tertiary care academic institution. The NPT7 demonstrated comparable precision to the ABL720 analyzers (coefficients of variation (CV) range = 0 to 4.9% and 0 to 7.8% for the NPT7 and ABL720 respectively). Correlation was excellent with regression slopes (0.88 to 1.05), intercepts (−2.76 to +7.60) and correlation coefficients (r = 0.9287 to 0.9980) (CV for duplicate differences range = 0.07 to 6.3% and 0.04 to 5.0% for the NPT7 and ABL720 analyzers excluding carboxyhemoglobin, methemoglobin, and deoxyhemoglobin analytes which were primarily in a low normal range). The internal QualityGuard system detected more errors (average 22 failures per analyzer) than traditional liquid controls (3 events). QualityGuard was able to monitor the entire analytical process and substitute for liquid controls in guaranteeing the quality of test results. With no required maintenance and intuitive operator interface, the NPT7 has application in a variety of settings.