Vasoactive Intestinal Peptide Gene Expression from Embryos to Aging Rats
作者:
Illana Gozes,
Pinhas Schächter,
Yael Shani,
Eliezer Giladi,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 47,
issue 1
页码: 27-31
ISSN:0028-3835
年代: 1988
DOI:10.1159/000124886
出版商: S. Karger AG
关键词: Vasoactive intestinal peptide-mRNA;Embryonal development;Aging
数据来源: Karger
摘要:
Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to 21-day-old rats. Our results suggest a role for the VIP gene protein products during embryonal development. During aging processes the decrease in VIP gene transcripts may be a consequence of either a reduction in the transcriptional activity of VIP neurons or death of VIP-producing cells.
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