首页   按字顺浏览 期刊浏览 卷期浏览 Vasoactive Intestinal Peptide Gene Expression from Embryos to Aging Rats
Vasoactive Intestinal Peptide Gene Expression from Embryos to Aging Rats

 

作者: Illana Gozes,   Pinhas Schächter,   Yael Shani,   Eliezer Giladi,  

 

期刊: Neuroendocrinology  (Karger Available online 1988)
卷期: Volume 47, issue 1  

页码: 27-31

 

ISSN:0028-3835

 

年代: 1988

 

DOI:10.1159/000124886

 

出版商: S. Karger AG

 

关键词: Vasoactive intestinal peptide-mRNA;Embryonal development;Aging

 

数据来源: Karger

 

摘要:

Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to 21-day-old rats. Our results suggest a role for the VIP gene protein products during embryonal development. During aging processes the decrease in VIP gene transcripts may be a consequence of either a reduction in the transcriptional activity of VIP neurons or death of VIP-producing cells.

 

点击下载:  PDF (943KB)



返 回