Neuroautoimmunity: Pathogenic Implications for Alzheimer’s Disease
作者:
Vijendra K. Singh,
期刊:
Gerontology
(Karger Available online 1997)
卷期:
Volume 43,
issue 1-2
页码: 79-94
ISSN:0304-324X
年代: 1997
DOI:10.1159/000213837
出版商: S. Karger AG
关键词: Alzheimer’s disease;Autoimmunity;Cell-mediated immunity;Aging;Inflammation
数据来源: Karger
摘要:
Immune factors such as cellular immunity, autoimmunity, and inflammation may play a pathogenic role in Alzheimer’s disease (AD), a neurodegenerative disorder. Based on immu-nologic dysregulation in many patients, a neuroautoimmunity (NAI) model is proposed which suggested a CD8+ cell-mediated mechanism (activated cytotoxic T lymphocytes); CD4+ suppressor/inducer (2H4+) cells may also be involved. Antibrain antibodies may contribute through a cell-specific autoimmune assault leading to neurodegeneration of the AD type. Thus, a cell-mediated autoimmune response against brain antigens may explain the immune subset of A
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