Tyrosine Aminotransferase in Senescent Rat Liver
作者:
A. Weber,
C. Guguen-Guillouzo,
M.F. Szajnert,
G. Beck,
F. Schapira,
期刊:
Gerontology
(Karger Available online 1980)
卷期:
Volume 26,
issue 1
页码: 9-15
ISSN:0304-324X
年代: 1980
DOI:10.1159/000212388
出版商: S. Karger AG
关键词: Rat;Liver;Tyrosine aminotransferase;Cross-re acting material;Glucocorticoids
数据来源: Karger
摘要:
We have studied tyrosine aminotransferase in the liver of adult and old rats. Thermostability and trypsin action were not modified, and no charge differences have been found by isoelectric focusing between ‘adult’ and ‘old’ enzymes. Inducibility by glucocorticoids was increased in vivo in these 27- to 31-month-old rats, but not in vitro, in cultured hepatocytes. Moreover, we have shown the absence of ‘cross-reacting material’ for tyrosine aminotransferase in senescent rat livers. The rapid turnover of this enzyme may explain the apparent absence of alterations d
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