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Synthesis of Amrinone, A Cardiotonic Agent

 

作者: Min‐Jen Shiao,   Puh Shieh,   Jen‐Shiow Lai,  

 

期刊: Journal of the Chinese Chemical Society  （WILEY Available online 1988）
卷期: Volume 35, issue 3  

页码: 233-236

 

ISSN:0009-4536

 

年代: 1988

 

DOI:10.1002/jccs.198800034

 

出版商: WILEY‐VCH Verlag

 

关键词: Amrinone;Cardiotonic Agent;3,4′‐bipyridine;N‐ethoxycarbonylpyridinium chloride;hydrogenolysis;Nitration;Bromination;Reduction

 

数据来源: WILEY

 

摘要:

AbstractA new synthesis of amrinone, 1, from 5‐(4‐pyridinyl) −2(1H)‐pyridone,5, is reported. Nitration at C‐3 of the pyridone ring of5followed by reduction afforded amrinone. Another synthetic route was also carried out by bromination at C‐3 of the pyridone ring of5followed by substitution with sodium azide to give the corresponding azide compounds8which was reduced

 

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