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Pyridazines 82[1]. Synthesis of Pyridazino[3,4‐b][1,5]benzodiazepin‐5‐ones and their Biological Evaluation as Non‐nucleoside HIV Reverse Transcriptase Inhibitors

 

作者: Gottfried Heinisch,   Elisabeth Huber,   Barbara Matuszczak,   Astrid Maurer,   Ulrike Prillinger,  

 

期刊: Archiv der Pharmazie  （WILEY Available online 1997）
卷期: Volume 330, issue 1‐2  

页码: 29-34

 

ISSN:0365-6233

 

年代: 1997

 

DOI:10.1002/ardp.19973300108

 

出版商: WILEY‐VCH Verlag

 

关键词: HIV‐1 reverse transcriptase inhibition;pyridazino[3,4‐b][1,5]benzodiazepin‐5‐ones;non‐nucleoside reverse transcriptase inhibitors

 

数据来源: WILEY

 

摘要:

AbstractStarting from 3,6‐dichloro‐N‐(2−chloro‐5‐nitrophenyl)‐pyrid‐azine‐4‐carboxamide (7) a series of 6,11‐dialkylated pyridazino‐[3,4‐b][1,5]benzodiazepin‐5‐ones with a 3−chloro‐8‐nitro, 8‐amino, 8‐acetylamino, or 8−chloro substitution pattern was preparedvia N‐alkyl‐3‐alkylamino‐6−chloro‐N‐(2−chloro‐5‐nitro‐phenyl)‐pyridazine‐4‐carboxamides. The new compounds were screened as non‐nucleoside reverse transcriptase inhibitors. The influence of the s

 

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