Effects of Methylguanidine on Sodium and Organic Ion Transport
作者:
Ming Li,
Soon Tong Chung,
Suk Ki Hong,
James M. Goldinger,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 60,
issue 3
页码: 349-354
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186777
出版商: S. Karger AG
关键词: Uremia;Uremic toxins;Methylguanidine;Natrium transport;Na+;K+ATPase;p-Aminohippurate;Tetraethylammonium
数据来源: Karger
摘要:
We studied the acute effect of methylguanidine (MG), a suspected uremic toxin that accumulates in renal failure, on p-aminohippurate (PAH) and tetraethylammonium (TEA) uptake in rabbit kidney slices, on Na+, K+ ATPase activity in the microsomal fraction of rabbit kidneys, and on transepithelial active Na transport across toad skin. MG at concentrations ranging from 0.05 (similar to that reported in uremic patients) to 1.0 ml does not affect the organic anion (PAH) uptake, although it exhibits a concentration-dependent inhibition of organic cation (TEA) uptake. MG at concentrations from 0.05 to 5 mM had no effect on kidney Na+, K+ 1 mM) stimulated Na transport when applied to the inside bathing solution. These results are not consistent with the hypothesis that MG is a potential uremic toxin that causes the natriuresis and other toxic effects. However, long-term toxic effecs of MG on the kidney were not assessed in the present study.
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