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Chromatin organization and restriction endonuclease activity on human metaphase chromosomes

 

作者: R. Mezzanotte,   U. Bianchi,   R. Vanni,   L. Ferrucci,  

 

期刊: Cytogenetic and Genome Research  （Karger Available online 1983）
卷期: Volume 36, issue 3  

页码: 562-566

 

ISSN:1424-8581

 

年代: 1983

 

DOI:10.1159/000131973

 

出版商: S. Karger AG

 

数据来源: Karger

 

摘要:

Human metaphase chromosomes were treated with Haelll, Hindlll, EcoRI, and Alul restriction endonucleases and subsequently stained with either Giemsa or ethidium bromide. The results obtained seemed to suggest that the structural organization of specific chromosome regions can play a primary role in determining the cytological effect after digestion with specific restriction endonucleases.

 

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