Effect of Simethicone on Lactulose-Induced H2Production and Gastrointestinal Symptoms
作者:
H. Friis,
S. Bodé,
J.J. Rumessen,
E. Gudmand-Høyer,
期刊:
Digestion
(Karger Available online 1991)
卷期:
Volume 49,
issue 4
页码: 227-230
ISSN:0012-2823
年代: 1991
DOI:10.1159/000200726
出版商: S. Karger AG
关键词: Simethicone;Carbohydrate malabsorption;H2excretion
数据来源: Karger
摘要:
The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind cross-over study, 10 healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H2 and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.
点击下载:
PDF
(480KB)
返 回