A multicenter trial of the use of the proteolytic enzyme inhibitor aprotinin in colorectal surgery
作者:
William Sheridan,
Ahmed Shandall,
John Alexander‐Williams,
Michael Keighley,
Paul Boulos,
Howard Young,
期刊:
Diseases of the Colon & Rectum
(OVID Available online 1989)
卷期:
Volume 32,
issue 6
页码: 505-508
ISSN:0012-3706
年代: 1989
出版商: OVID
关键词: Proteolytic enzyme inhibition;Aprotinin;Collagen;Anastomotic healing;Colon
数据来源: OVID
摘要:
&NA;Animal studies have demonstrated the value of the proteolytic enzyme inhibitor, aprotinin, in reducing collagen breakdown and improving the healing of experimental colonic anastomoses. A double‐blind, multicenter, prospective trial has evaluated the use of aprotinin in the prevention of anastomic leakage in patients. Two hundred sixteen patients undergoing colonic resection and anastomosis were studied. Patients were randomized to receive either aprotinin or placebo intravenously, peroperatively, and for the first three postoperative days. Anastomotic integrity was assessed clinically and by Hypaque®enema on the tenth postoperative day. Although the use of aprotinin was not associated with a significant overall decrease in anastomotic leakage rates, in 95 patients undergoing anterior resection, leakage rates in those receiving aprotinin (clinical 10.8 percent; radiologic 32.4 percent) were lower than in those receiving placebo (17.2 percent and 43.1 percent, respectively). An apparent adverse association was noted, however, in patients undergoing left hemicolectomy or sigmoid colectomy who received aprotinin.
点击下载:
PDF
(329KB)
返 回