Retinoic acid and pigment cells: a review ofin‐vitroandin‐vivostudies
作者:
J.‐P. ORTONNE,
期刊:
British Journal of Dermatology
(WILEY Available online 1992)
卷期:
Volume 127,
issue S41
页码: 43-47
ISSN:0007-0963
年代: 1992
DOI:10.1111/j.1365-2133.1992.tb16987.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SummaryTopical tretinoin improves mottling and hyperpigmented lesions of photodamaged skin. The basic mechanisms underlying these effects are not known. It is demonstrated that retinoids inhibit the growth and enhance the differentiation of melanoma cellsin vitro, and stimulate the constitutive melanogenesis in melanoma cellsin vitro.On the other hand, they inhibit hormonally or pharmacologically induced melanogenesis in these cells. Very few data are available concerning the effect of retinoic acid on normal human melanocytes, but there is some inhibition of growth as in melanoma cells. Retinoic acid appears to have little effect on the melanogenesis of normal human melanocytes grownin vitrousing serum‐free culture medium. Changes in the shape of these melanocytes suggest that retinoic acid acts on cytoskeleton proteins. Further studies, bothin vitroandin vivo, are needed to clarify the effects of retinoic acid on melanocyte
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