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The Molecular Defects ofα-Thalassemia in the Filipino

 

作者: DozyA. M.,   KabischH.,   BakerJ.,   KoenigH. M.,   KurachiS.,   StamatoyannopoulosG.,   ToddD.,   KanY. W.,  

 

期刊: Hemoglobin  （Taylor Available online 1977）
卷期: Volume 1, issue 6  

页码: 539-546

 

ISSN:0363-0269

 

年代: 1977

 

DOI:10.3109/03630267709003418

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

Molecular hybridization with synthetic radioactive DNA (cDNA) complementary to a globin mRNA sequences shows that, as in most other Southeast Asian populations, the a globin structural genes are deleted in Filipinos affected by theα-thalassemia syndromes. Thus, all 4α-globin structural genes are deleted in homozygousα-thalassemia with hydrops fetalis, 3 and 2 structural genes are deleted in hemoglobin H disease andα-thalassemia-1 respectively.

 

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