ARTERIAL AND VENOUS EFFECTS OF VERAPAMIL IN NORMAL VOLUNTEERS
作者:
C. THUILLEZ,
P. DUHAZE,
C. FOURNIER,
V. LAPIERRE,
J.‐F. GIUDICELLI,
期刊:
Fundamental&Clinical Pharmacology
(WILEY Available online 1987)
卷期:
Volume 1,
issue 1
页码: 35-44
ISSN:0767-3981
年代: 1987
DOI:10.1111/j.1472-8206.1987.tb00543.x
出版商: Blackwell Publishing Ltd
关键词: calcium antagonist;verapamil;pulsed Doppler;arterial effect;venous effect;healthy volunteer
数据来源: WILEY
摘要:
Summary—1The effects of verapamil (120 mg orally) and a placebo on arterial pressure, heart rate, PR interval, arterial flows and diameters of the brachial and carotid arteries (pulsed Doppler technique), forearm vascular resistance, and venous diameter and compliance (cutaneous microstrain gauge and plethysmography) have been compared over a 10‐hr period in six healthy volunteers during a double‐blind and cross‐over study.2Verapamil reduced diastolic blood pressure by approximately 10 mm Hg, did not affect heart rate and increased PR interval by approximately 15%.3Verapamil significantly increased brachial and carotid arterial blood flows by 56% (P<0.01) and 16% (P<0.05), respectively, but the diameters of these vessels were not significantly modified (+ 7 and + 4%, respectively, NS). Forearm vascular resistance decreased by 40% (P<0.01), indicating that verapamil preferentially dilates small arteries. All these effects peaked at 2 h after drug intake and lasted for 6 h.4Verapamil increased hand dorsal vein diameter and flow by 95% (P<0.05) and 80% (P<0.05), respectively, from 2 to 4 h after drug intake but venous compliance, assessed by the venous diameter/venous flow ratio, was not significantly modified (from 0.71 to 0.69, NS), thus indicating that veins are not directly affected by th
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