Expression ofβ2−microglobulin on hepatocytes in acute and chronic type B hepatitis
作者:
Yukihisa Nagafuchi,
Professor Peter J. Scheuer,
期刊:
Hepatology
(WILEY Available online 1986)
卷期:
Volume 6,
issue 1
页码: 20-23
ISSN:0270-9139
年代: 1986
DOI:10.1002/hep.1840060105
出版商: W.B. Saunders
数据来源: WILEY
摘要:
Abstractβ2−Microglobulin display was examined in 131 liver biopsies from patients with acute and chronic type B hepatitis, using an indirect immunoperoxidase method. Enhanced expression of β2−microglobulin on hepatocyte membranes was observed in patients with acute hepatitis, chronic active hepatitis with moderate to severe activity and cirrhosis, when compared with normal liver. In acute hepatitis, β2−microglobulin‐positive hepatocytes were mainly observed in perivenular areas in association with bridging necrosis. In chronic hepatitis, β2−microglobulin‐positive hepatocytes were observed mainly in periportal zones and in some areas of lobular activty.Diffuse‐enhanced display of β2−microglobulin on hepatocytes was observed in 5 of 6 patients treated with lymphoblastoid interferon as part of a trial of antiviral therapy. The mechanism by which β2−microglobulin display is enhanced on hepatocytes in patients not treated with interferon is uncertain. However, display of β2−microglobulin on hepatocytes probably reflects display of HLA‐A, B and C antigens and may influence the course of hepatitis B virus infection by increasing susceptibility of the affectedcells to T
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