Fecal Calprotectin Levels in Healthy Children Studied With an Improved Assay
作者:
Ulrika Fagerberg,
Lars Lööf,
Rumjana Merzoug,
Lars-Olof Hansson,
Yigael Finkel,
期刊:
Journal of Pediatric Gastroenterology and Nutrition
(OVID Available online 2003)
卷期:
Volume 37,
issue 4
页码: 468-472
ISSN:0277-2116
年代: 2003
出版商: OVID
关键词: Calprotectin;Feces;Children;Reference values;Inflammatory bowel disease
数据来源: OVID
摘要:
BackgroundCalprotectin is a protein abundant in neutrophils. Fecal calprotectin can be used as a marker of gastrointestinal inflammation, and an improved assay has recently been developed. The aim of this study was to establish reference values for fecal calprotectin in healthy children aged between 4 and 17 years.MethodsFecal samples were obtained from 117 healthy children classified into four age groups: 4 to 6 years, 7 to 10 years, 11 to 14 years, and 15 to 17 years. A health questionnaire was used to ensure that these children fulfilled the inclusion criterion and did not have intercurrent disease, nasal or menstrual bleeding, or nonsteroidal anti-inflammatory drug medication before the sampling period. Calprotectin was analyzed using a quantitative enzyme-linked immunosorbent assay (Calprest, Eurospital SpA, Trieste, Italy). Children with fecal calprotectin values >50 &mgr;g/g were asked to deliver an additional sample.ResultsThe overall median fecal calprotectin concentration was 13.6 &mgr;g/g (95% confidence interval, 9.9–19.5 &mgr;g/g) in the 117 children. In the different age groups, 4 to 6 years, 7 to 10 years, 11 to 14 years, and 15 to 17 years, the median calprotectin concentrations were 28.2, 13.5, 9.9, and 14.6 &mgr;g/g, respectively. Of these children, 104 (89%) had a concentration <50 &mgr;g/g. The remaining 13 children with a calprotectin concentration >50 &mgr;g/g delivered one additional fecal sample. All showed a lower concentration in the second sample except for one teenager who later proved to have proctitis.ConclusionsThe suggested cutoff level for adults (<50 &mgr;g/g) can be used for children aged from 4 to 17 years regardless of sex. A fecal calprotectin concentration >50 &mgr;g/g warrants follow-up.
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