Sterol and Triterpene Derivatives from Plants Inhibit the Effects of a Tumor Promoter, and Sitosterol and Betulinic Acid Inhibit Tumor Formation in Mouse Skin Two-Stage Carcinogenesis
作者:
K. Yasukawa,
M. Takido,
T. Matsumoto,
M. Takeuchi,
S. Nakagawa,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 1
页码: 72-76
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226898
出版商: S. Karger AG
关键词: Antitumor promoter;Two-stage carcinogenesis;Ornithine decarboxylase;12-O-Tetradecanoylphorbol-13-acetate;Betulinic acid;Sitosterol;Sterols;Triterpenes;Saponins;Plant constituent
数据来源: Karger
摘要:
A single topical application of 1 jag of 12–O-tetradecanoylphorbol-13-acetate (TPA) to the ears of mice was shown to induce edema, and this TPA-induced inflammation was inhibited by 4-methylsterol and triterpene derivatives. The ED50 of these compounds against TPA-induced inflammation was 0.1–3 μmol. Phytosterols had only slight inhibitory effects. Furthermore, application of 5 μg TPA to mouse skin rapidly caused accumulation of ornithine decarboxylase (ODC). Similarly, sitosterol and lupane-type triterpene derivatives markedly inhibited this TPA-induced ODC accumulation. In addition, 5 umol betulinic acid markedly inhibited the promoting effect of 2.5 μg TPA applied twice weekly on skin tumor formation in mice initiated with 50 ug of 7,12-dimethylbenz[a]anthracene, and 5 μmol of sitosterol caused slight suppression. Thus, the inhibitory effects of sterol and triterpene derivatives on TPA-induced inflammation roughly parallelled their inhibitory activities against tumor pr
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