Detection of Picogram Levels of Sufentanil by Capillary Gas Chromatography
作者:
Stephen Weldon,
Dana Perry,
Randall Cork,
A. Gandolfi,
期刊:
Anesthesiology
(OVID Available online 1985)
卷期:
Volume 63,
issue 6
页码: 684-687
ISSN:0003-3022
年代: 1985
出版商: OVID
关键词: Anesthetics, intravenous: sufentanil;Metabolism: metabolites;Pharmacokinetics: sufentanil
数据来源: OVID
摘要:
Sufentanil and its two primary metabolites, N-(4-[methoxymethyl]-4-piperidinyl)-N-phenyl propanamide (MPPP), and N-(4[hydroxymethyl]-1-[2-thienylethyl]-4-piperidinyl)-N-phenyl propanamide (desmethyl sufentanil), were detected by capillary gas chromatography with a nitrogen-phosphorous detector. The detection limit for sufentanil and its metabolites is 30–50 pg/ml with minimal interfering substances in the chromatograms. This method allowed for the detection of serum sufentanil in the terminal elimination phase of sufentanil in a patient receiving 1.5 μg/kg and will allow for studies to determine the pharmacokinetics and metabolism of sufentanil in a wide variety of patient groups now receiving this agent.
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