Ciprofloxacin Ointment Versus Ciprofloxacin Drops for Therapy of Experimental Pseudomonas Keratitis
作者:
Jeffery Hobden,
Richard O'Callaghan,
Michael Insler,
James Hill,
期刊:
Cornea
(OVID Available online 1993)
卷期:
Volume 12,
issue 2
页码: 138-141
ISSN:0277-3740
年代: 1993
出版商: OVID
关键词: Ciprofloxacin;Cornea;Ointment;Pseudomonas
数据来源: OVID
摘要:
To compare the efficacy of ciprofloxacin hydrochloride ointment with that of ciprofloxacin drops for treatment of experimental ρseudomonas keratitis, rabbit eyes were infected by intrastromal injection of 103colony-forming units (CFU) log-phaseP.aeruginosa. Infected and uninfected eyes were treated with either 0.3% ciprofloxacin ointment applied hourly for 6 h or 0.3% ciprofloxacin drops applied every 15 min for 6 h. Infected eyes treated with the ointment or drop vehicle alone served as placebo controls. Ciprofloxacin ointment significantly reduced the number of viable bacteria (CFU) per cornea more than four logs compared to the placebo control (ρ<0.0001). Ciprofloxacin drops significantly reduced the number of bacteria (CFU) per cornea >7 logs as compared with placebo-treated controls (ρ<0.0001). Ciprofloxacin ointment may be a useful adjunct to conventional topical drops for therapy of bacterial keratitis.
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