Distribution of PDE4A and Goαimmunoreactivity in the accessory olfactory system of the mouse
作者:
Yanny Lau,
James Cherry,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 1
页码: 27-30
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: Accessory olfactory bulb;cAMP phosphodiesterase;G protein;Vomeronasal organ;Pheromone;Zonal organization
数据来源: OVID
摘要:
Distribution of the cAMP-specific phosphodiesterase PDE4A was examined in the accessory olfactory system by immunohistochemistry. Adjacent sections through the vomeronasal organ (VNO) and accessory olfactory bulb (AOB) were alternately immunostained with antibodies against PDE4A or the G-protein α subunit Goα, which labels basal VNO neurons, in order to determine whether PDE4A occurs preferentially in one of two segregated VNO pathways. We found that PDE4A strongly labeled apical VNO neurons and rostral AOB glomeruli. There was virtually no overlap in Goαand PDE4A staining, and there were no regions of the VNO neuroepithelium or AOB glomeruli not labeled by either antibody. These results identify a potential member of the pheromone transduction cascade in apical neurons, and provide further evidence that the VNO consists of functionally distinct pathways.
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