Inhibition of Experimental Hypercholesterolemia and Atherogenesis by 4‐Amino Pteroylglutamic Acid (Aminopterin)
作者:
Carl Muschenheim,
Seymour Advocate,
Donald Hoskins,
期刊:
Circulation Research
(OVID Available online 1960)
卷期:
Volume 8,
issue 4
页码: 759-764
ISSN:0009-7330
年代: 1960
出版商: OVID
数据来源: OVID
摘要:
Rabbits pretreated with Aminopterin (4-amino pteroylglutamic acid) for 4 weeks were fed an atherogenic diet for 8 weeks, during which Aminopterin injections also were continued. The atherogenic diet consisted of a stock diet with 3/4 per cent cholesterol added. As a result of some manipulation of the Aminopterin dosage during the period before cholesterol feeding was begun, some of the Aminopterin-treated animals lost weight from overdosage, and 7 of the original 20 died. The surviving animals upon reduction of dosage made good weight gains, comparable to the controls, during the cholesterol feeding period. When sacrificed after 8 weeks of cholesterol feeding, the control animals, 21 in number, all had grossly demonstrable 1+ to 4+ atheromatosis of the aorta. Of the 13 surviving Aminopterin-treated animals, 9 had no atheromatosis or doubtful deposits of minimal extent. Only 4 had definite atheromatosis comparable in extent to the controls. Serum cholesterol levels were 30 to 50 per cent lower in the treated animals than in the controls.
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