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Regulation of sensorimotor gating by interactions of dopamine and adenosine in the rat

 

作者: M Koch,   W Hauber,  

 

期刊: Behavioural Pharmacology  (OVID Available online 1998)
卷期: Volume 9, issue 1  

页码: 23-29

 

ISSN:0955-8810

 

年代: 1998

 

出版商: OVID

 

关键词: acoustic startle response;adenosine;apomorphine;dopamine;prepulse inhibition;rat;schizophrenia

 

数据来源: OVID

 

摘要:

Prepulse inhibition (PPI) of the acoustic startle response is a behavioural tool used to assess sensorimotor gating processes and its disturbances in rats and in humans. PPI in rats is reduced by an overactivity of the dopamine (DA) system. Because there are functional interactions between DA and adenosine receptors, we tested whether PPI can be influenced by the mixed DA receptor agonist apomorphine (APO) and by the unselective adenosine antagonist theophylline (THEO). Combined administration of APO (0.5 mg/kg, i.p.) and THEO (20 mg/kg, i.p.) in doses devoid of significant effects on their own significantly reduced PPI. The PPI-disrupting effect of the combined THEO plus APO treatment was dose-dependently antagonized by co-administration of the selective adenosine A1agonist CPA (0.15–1.5 mg/kg, i.p.), but not by the A2Aagonist CGS21680 (0.1–2 mg/kg, i.p.). These data demonstrate that antagonistic interactions between DA and adenosine, involving adenosine A1receptors, play an important role in the regulation of PPI. The possible implications of these findings for the use of adenosine agonists in the treatment of schizophrenia are discussed.

 

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