Procollagen Type I C-Terminal Extension Peptide in Predialysis Chronic Renal Failure
作者:
Giorgio Coen,
Sandro Mazzaferro,
Paola Ballanti,
Ermanno Bonucci,
Franco Bondatti,
Micaela Manni,
Marzia Pasquali,
Italia Perruzza,
Daniela Sardella,
Antonella Spurio,
期刊:
American Journal of Nephrology
(Karger Available online 1992)
卷期:
Volume 12,
issue 4
页码: 246-251
ISSN:0250-8095
年代: 1992
DOI:10.1159/000168453
出版商: S. Karger AG
关键词: Procollagen type 1;Bone formation parameters;Osteocalcin;Parathyroid hormone;1;2 5-dihydroxy vitamin D3;Nondialytic chronic renal failure
数据来源: Karger
摘要:
Collagen type 1 is the most abundant protein of bone. Serum levels of type 1 procollagen carboxy-terminal extension peptide (Procoll-1-C) may give a measure of the rate of synthesis of the collagen of bone and be therefore a marker of bone turnover. We have studied 38 patients with predialysis chronic renal failure; 14 of them were under long-term treatment with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] for prevention of secondary hyperparathyroidism. In all patients a transiliac bone biopsy for histomorphometry and determination of dynamic parameters was performed following double tetracycline labeling. In addition serum Procoll-1-C, intact and C-terminal parathyroid hormone (PTH), osteocalcin and alkaline phosphatase were determined. In the patients not receiving 1,25(OH)2D3, serum levels of Procoll-1-C were higher than normal. Procoll-1-C did not correlate with any of the humoral parameters, including serum creatinine, nor with static histomorphometric parameters. Con-trarily to osteocalcin, the collagen type 1 marker correlated significantly with all dynamic parameters. Treatment with 1,25(OH)2D3 was accompanied by lower levels of osteocalcin, iPTH (n.s.), osteoblastic surface and by normal levels of Procoll-1-C (p < 0.001, compared to untreated patients), without substantial change in bone formation parameters (bone formation rate). In conclusion Procoll-1-C in predialysis chronic renal failure is a marker of bone turnover unparalleled by other markers. 1,25(OH)2D3 administration is associated with lower serum levels of the peptide unaccompanied by a decrement of bone formation parameters, therefore with an apparently better utilization of collagen type 1 in the mineralization process. The role of PTH in the procollagen type 1 synthesis in predialysis chronic renal failure remains undetermined.
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