Genetics of subdivided populations and its relationships with certain measures of association
作者:
C. C. Li,
G. P. Vogler,
期刊:
Genetic Epidemiology
(WILEY Available online 1991)
卷期:
Volume 8,
issue 1
页码: 1-11
ISSN:0741-0395
年代: 1991
DOI:10.1002/gepi.1370080102
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: population subdivided;multiple alleles;contingency table;reliability measure;subdivided population;inbreeding coefficient;agreement measure;association measure
数据来源: WILEY
摘要:
AbstractUnlike inbreeding, population subdivision affects different genotypes differently for multiple alleles, so that the simple relationship between inbreeding and subdivision for two alleles no longer holds for all genotypes. In this communication, the detailed effects of subdivision have been studied for three alleles with results easily generalized to any number of alleles. Then an average effect of subdivision is proposed. This average effect of subdivision is found to play the same role as the inbreeding coefficient for multiple alleles, so that the overall relationship between inbreeding and subdivision may be reestablished again. In the final section, we discuss the relationship of the genetic result with measures of association of square contingency tables arising from epidemiological, social studies, educational and psychological studies.
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