An Application of Mass Fragmentography to the Determination of Acetazolamide in Body Fluids
作者:
Kenichi Kishida,
Reizo Manabe,
Keiichi Bando,
Yoshihiro Miwa,
期刊:
Analytical Letters
(Taylor Available online 1981)
卷期:
Volume 14,
issue 5
页码: 335-347
ISSN:0003-2719
年代: 1981
DOI:10.1080/00032718108081409
出版商: Taylor & Francis Group
关键词: Acetazolamide;Mass Fragmentography;Single Ion Detection;Multiple Ion Detection
数据来源: Taylor
摘要:
A reliable mass fragmentographic determination method for acetazolamide levels in body fluids was developed to favor the pharmacokinetic study on the patients receiving multiple doses. The use of 2-(N-propionamido)-1,3,4-thiadiazole-5-sulfonamide as the internal standard permitted the internal standard to be added to the sample before the extraction, and enabled the single ion measurement at m/e 249. Single ion measurement at m/e 249 detected 25 pg of acetazolamide. Multiple ion detection at m/e 249, 264 and 278 favored more accurate identification of each compound on the chromatogram. The assay results of the samples from volunteers were consistent with the ones reported elswhere.
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