The binocular depth of focus of monovision wearers was compared to the sum of the two monocularly determined depths of focus. Observers fell into three groups based upon ocular sighting dominance. Complete binocular summation of the monocular depths of focus was observed in subjects without a preferred fixating eye. Subjects who preferred to fixate with one eye had difficulty suppressing blur of that eye while the binocular target was within the depth of focus of the nonpreferred eye. A third group showed partial summation of the two monocular depths of focus. Similar patterns of accommodative response, measured objectively with the SRI optometer, were observed in subjects wearing monovision corrections. Accommodative response to sinusoidal variations in blur was controlled primarily by the dominant sighting eye. These results demonstrate the effectiveness of interocular suppression of anisometropic blur in monovision correction and the influence of ocular dominance upon this suppression process.