Benzoyl cellulose beads in the pure polymeric form as a new powerful sorbent for the chromatographic resolution of racemates
作者:
Eric Francotte,
Romain M. Wolf,
期刊:
Chirality
(WILEY Available online 1991)
卷期:
Volume 3,
issue 1
页码: 43-55
ISSN:0899-0042
年代: 1991
DOI:10.1002/chir.530030109
出版商: Wiley‐Liss, Inc.
关键词: beads;polymer;enantiomer;chiral phase;interaction;alcohol;diol
数据来源: WILEY
摘要:
AbstractCellulose‐based stationary phases are known to be very efficient and versatile chiral sorbents for the chromatographic resolution of racemates. Except for microcrystalline cellulose triacetate (CTA I), basically all other cellulose‐based phases have been prepared by coating of ca. 20% weight polymer on a wide pore silica gel used as a carrier. In this work we describe the preparation of benzoylcellulose (TBC) beads in the pure polymeric form (without inorganic carrier) from an emulsion of the organic polymer. The new material has been fully characterized and used as a chiral stationary phase for the resolution of various classes of racemic compounds such as benzylic alcohols or acetate derivatives of aliphatic alcohols and diols. The structural variety of the separated solutes as well as the irrational influence of the aromatic substituent in different classes of aryl compounds suggest that multiple interaction sites are involved in the complexation, making a prediction of the separation difficult. The benzoyl cellulose beads exhibit a very high loading capacity, which is particularly useful for preparative purposes as demonstrated for selected examp
点击下载:
PDF
(1201KB)
返 回