ABSTRACT:A 27‐year‐old woman with intestinal lymphangiectasia and congenital lymphedema developed cryptococ‐cal cellulitis as a result of her underlying depressed cell‐mediated immune responsiveness. Prompt therapy with amphotericin B and 5‐fluorocytosine resulted in an excellent outcome. The authors believe that the increasing population of patients with depression of cellmediated immune response will lead to an increase in the frequency with which cryptococcal cellulitis is seen and emphasize that proper evaluation of a patient with presumptive cellulitis includes consideration of fungal, as well as bacterial,