Continuous Duodenal Infusions of LevodopaPlasma Concentrations and Motor Fluctuations in Parkinson's Disease
作者:
J. Sage,
L. Schuh,
R. Heikkila,
R. Duvoisin,
期刊:
Clinical Neuropharmacology
(OVID Available online 1988)
卷期:
Volume 11,
issue 1
页码: 36-44
ISSN:0362-5664
年代: 1988
出版商: OVID
关键词: Levodopa;Parkinson's disease;On-off phenomenon;Duodenal infusion.
数据来源: OVID
摘要:
Summary:Four parkinsonian patients received continuous duodenal infusions of levodopa (LD) for severe “on-off” phenomena associated with Sinemet (carbidopa/levodopa) therapy. All patients had marked decreases in motor fluctuations on the infusions compared with tablets. Two factors that appear related to this improvement are the ability of duodenal infusions to produce steadier plasma LD concentrations and/or to maintain LD concentrations above a minimum threshold needed to achieve the “on” state.
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