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Synthesis of75Se‐2‐phenyl‐1,2‐benzisoselenazol‐3(2H)‐one (PZ 51; ebselen. A novel biologically active organo‐selenium compound

 

作者: R. Cantineau,   G. Tihange,   A. Plenevaux,   L. Christiaens,   M. Guillaume,   A. Welter,   N. Dereu,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1986）
卷期: Volume 23, issue 1  

页码: 59-65

 

ISSN:0362-4803

 

年代: 1986

 

DOI:10.1002/jlcr.2580230108

 

出版商: John Wiley&Sons, Ltd.

 

关键词: 75Se‐radiosynthetics;2‐phenyl‐1,2‐benzisoselenazol‐3(2H)‐one;PZ 51;ebselen

 

数据来源: WILEY

 

摘要:

AbstractThe preparation of75Se‐ebselen (75Se‐PZ 51) in a high radiochemical yield (∼40 %) and with a specific activity of 240 mCi/mM (8.9 GBq/mM) is described. It entails a very simple, fast and one‐pot procedure starting from elemental75Se‐selenium.75Se‐diselenosalicylic acid4is initially prepared as the key intermediate which is transformed into a corresponding dichloride5‐before reacting with aniline to yield the desired75Se‐ebselen.Identity and purity of the labelled compound were controlled by comparison in TLC, HPLC and MS with an authent

 

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