Normal Salivary Mucin Contains the Gastrointestinal Cancer‐Associated Antigen Detected by Monoclonal Antibody 19–9 in the Serum Mucin of Patients1
作者:
Manfred Brockhaus,
Marie Wysocka,
John L. Magnani,
Zenon Steplewski,
Hilary Koprowski,
Victor Ginsburg,
期刊:
Vox Sanguinis
(WILEY Available online 1985)
卷期:
Volume 48,
issue 1
页码: 34-38
ISSN:0042-9007
年代: 1985
DOI:10.1111/j.1423-0410.1985.tb00142.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractMonoclonal antibody 19–9 produced by a hybridoma prepared from spleen cells of a mouse immunized with a human colon carcinoma cell line, detects an antigen in sera from many patients with gastrointestinal and pancreatic cancer. This antibody is directed against a carbohydrate with the sugar sequenceNeuNAcα2–3Galβ1‐3GlcNAcα1–3Gal…4 1 Fucα1In many gastrointestinal and pancreatic cancers this sequence occurs in a monosialoganglioside containing a sialylated Lea‐active pentasaccharide (sialylated lacto‐N‐fucopentaose II, IV3‐α‐NeuNAc‐III4‐α‐Fuc‐LcOse4). In the sera of cancer patients the antigen occurs as a mucin. The antigen is also found in salivary mucin from many normal individuals belonging to the Le(a+b‐) or Le(a‐b+) blood group but not in salivary mucin from normal individuals belonging to the Le(a‐b‐) blood group. There is more antigen in mucin from individuals belonging to the Le(a+b‐) blood group than in mucin from indivi
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