Ethanol elimination rates were measured in 7 baboons fed alcohol for 2–7 yr (and their controls) by using a constant ethanol infusion to maintain blood ethanol at three different levels; 5, 10, and 50 mM. Ethanol elimination rates were significantly faster at a blood ethanol level of 50 mMthan at 10 or 5 mMin both alcohol‐fed and control animals. The difference between 50 mMand 5 mMconcentration was 36% in alcohol‐fed and 25% in control animals. In baboons fed ethanol chronically, the ethanol elimination rates were significantly faster than in pair‐fed controls at 50 mM(179 ± 10.0 mg/kg/hr versus 144 ± 9.8) and at 10 mM(148 ± 4.1 versus 114 ± 8.2), but not at 5 mM. Even if one takes into account the extrahepatic losses, these differences cannot be explained solely by the elimination of ethanol through the lowKmalcohol dehydrogenase pathway, and these observations indicate that a non‐ADH system significantly contributes to ethanol elimination in vivo, especially in alcoho