Effect of nitric oxide on the oxygen transport of human erythrocytes
作者:
Kazunori Kon,
Nobuji Maeda,
Takeshi Shiga,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1977)
卷期:
Volume 2,
issue 5
页码: 1109-1113
ISSN:0098-4108
年代: 1977
DOI:10.1080/15287397709529508
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The oxygen dissociation curve of partially NO‐liganded hemoglobin of human erythrocytes is measured. As the percentage of NO ligation increases, the affinity of nonliganded hemoglobin for oxygen increases and the heme‐heme interaction decreases; furthermore, methemoglobin is formed. Therefore, NO affects the oxygen transport function of hemoglobin, decreasing the oxygen supply to peripheral tissues, because of (1) simple diminution of the available hemoglobin by the tightly bound NO, (2) the high affinity of hemoglobin for oxygen, and (3) the inevitable formation of methemoglobin.
点击下载:
PDF (239KB)
返 回