Oncogenic response of strain A/J mice to inhaled chemicals
作者:
Bernard Adkins,
EthardW. Van Stee,
JaneEllen Simmons,
ScotL. Eustis,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1986)
卷期:
Volume 17,
issue 2-3
页码: 311-322
ISSN:0098-4108
年代: 1986
DOI:10.1080/15287398609530825
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Strain A/J mice were exposed by inhalation for 6 h/d, 5 d/wk, for 6 mo to carbon disulfide, 1,2‐dibromoethane, ethylene oxide, naphthalene, nitrogen dioxide, or vinyl chloride. Significant increases in pulmonary adenoma formation were observed following exposure to 300 ppm carbon disulfide; 20 and 50 ppm 1,2‐dibromoethane; 70 and 200 ppm ethylene oxide; 10 ppm nitrogen dioxide; and 50, 200, and 500 ppm vinyl chloride comapred to control animals. Repeated studies with 1,2‐dibromoethane, ethylene oxide, and vinyl chloride gave similarly significant results. Exposure of mice to 30 ppm naphthalene did not elicit a significant adenoma response. Histopathological examination of lungs from animals in these studies revealed multiple alveolar adenomas. Results from earlier studies with these chemicals, using strain A mice and Swiss mice, and bioassay information with rats and mice were compared with these data. These results provide further information for the validation of thisin vivomodel as a tool for predicting oncogenic potential following chemical exposure.
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