A simple, rapid and precise high-performance liquid chromatographic assay of meclizine in tablets has been developed. Reversed-phase chromatography was conducted using a mobile phase of acetonitrile and water (30% V/V) and detection at 230 nm. The recovery and coefficient of variation from six placebo tablets containing 25 mg of meclizine were 100.5% and 0.84%, respectively. Replicate regression analyses of three standard plots in the concentration range of 1–12 mcg/ml obtained on three different days gave a correlation coefficient >0.998 and the coefficient of variation of the slopes <1%. The assay was precise within day and between days as indicated by ANOVA test. The recoveries from 10 replicate tablets of the two different commercial meclizine brands were 98.5 and 100.7% of the label amount and their coefficients of variation were 1.16 and 1.71%.