Sequence‐dependent modification of Trp by the Pmc protecting group of Arg during TFA deprotection
作者:
ALENA STIERANDOVÁ,
NIKOLAI F. SEPETOV,
GREGORY V. NIKIFOROVICH,
MICHAL LEBL,
期刊:
International Journal of Peptide and Protein Research
(WILEY Available online 1994)
卷期:
Volume 43,
issue 1
页码: 31-38
ISSN:0367-8377
年代: 1994
DOI:10.1111/j.1399-3011.1994.tb00373.x
出版商: Blackwell Publishing Ltd
关键词: SPPS;side reactions;Pmc;Trp modification;scavenger mixtures;cotton;sequence dependence
数据来源: WILEY
摘要:
The extent of transfer of the Pmc protecting group from the guanidino group of arginine to the side chain of tryptophan depends on the spacial distance of these side chains. When these two amino acids are separated by one amino acid, the transfer of the Pmc protecting group is the most pronounced, and it cannot be completely prevented by the use of currently utilized scavenger mixtures. The extent of this side reaction also depends on the amino acid separating the arginine and tryptophan residues and position of tryptophan within the peptide chain as well as on the type of the solid‐phase carrie
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