A Case of POEMS Syndrome Showing Elevated Serum Interleukin 6 and Abnormal Expression of Interleukin 6 in the Kidney
作者:
Atsushi Fukatsu,
Yasuhiko Ito,
Yukio Yuzawa,
Futoshi Yoshida,
Masataka Kato,
Kouichirou Miyakawa,
Seiichi Matsuo,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 62,
issue 1
页码: 47-51
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186994
出版商: S. Karger AG
关键词: Interleukin 6;POEMS syndrome;Mesangium;Endothelium
数据来源: Karger
摘要:
A 46-year-old female presented with POEMS syndrome. Hemodialysis was initiated to control severe anasarca and declining renal function. Corticosteroids were effective in treating renal insufficiency and other symptoms. Serum interleukin 6 (IL-6) was elevated before the corticosteroid therapy but returned to the normal level under the therapy. Immunostaining for the kidney tissue obtained by a renal biopsy showed a diffuse distribution of IL-6 in the glomeruli; thus, in contrast to normal, IL-6 was detected not only in mesangial cells but also in endothelial cells. IL-6 was also distributed in capillaries in the interstitium. While these results suggest a pathogenic role of IL-6 in POEMS syndrome, other factors may be necessary for the full expression of symptoms. Furthermore, it is suggested that chronically stimulated glomerular endothelial cells are capable of producing IL-6.
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